Rosiptor acetate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 782487-29-0 | Cat. No. | BCP24919 |
| Related Products | 782487-28-9（Rosiptor） | ||
| Name | Rosiptor acetate | ||
| Synonyms | AQX-1125 acetate;AQX1125 acetate;AQX 1125 acetate; | ||
| SMILES | CC(=O)O.CC1(CCC(CC1CO)O)C2CCC3(C(C2CN)CCC3=C)C | ||
| Chemical Name | |||
| Formula | C22H39NO4 | M. Wt | 381.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases. | ||
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