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ROCK

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ROCK

Chemical Structure Cat. No. Product Name CAS No.
GSK180736A Chemical Structure
 BCP25022 GSK180736A 817194-38-0
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
H-1152 Dihydrochloride Chemical Structure
 BCP25257 H-1152 Dihydrochloride 871543-07-6
H-1152 dihydrochloride is an isoquinolinesulfonamide derivative that is a membrane-permeable inhibitor of Rho-kinase but poor inhibitor of other serine/threonine kinases.
WAY-624704 Chemical Structure
 BCP46784 WAY-624704 692869-38-8
WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM.
Cotosudil Chemical Structure
 BCP44925 Cotosudil 1258833-31-6
Cotosudil is a Rho-associated (ROCK) kinase inhibitor.
Belumosudil mesylate Chemical Structure
 BCP41838 Belumosudil mesylate 2109704-99-4
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
CMPD101 Chemical Structure
 BCP37871 CMPD101 865608-11-3
CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure.
TC-S 7001 Chemical Structure
 BCP34134 TC-S 7001 867017-68-3
TC-S 7001 is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively.
Y-27632 Dihydrochloride Hydrate Chemical Structure
 BCP26044 Y-27632 Dihydrochloride Hydrate 331752-47-7
Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively, which primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.
CCG-222740 Chemical Structure
 BCP31985 CCG-222740 1922098-69-8
CCG-222740 is a potent and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 also is a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.
Ripasudil Hydrochloride Chemical Structure
 BCP24238 Ripasudil Hydrochloride 223644-02-8
Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively.
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