BVT948 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 39674-97-0 | Cat. No. | BCP45529 |
| Name | BVT948 | ||
| Synonyms | BVT-948; BVT 948; SPS8I3; SPS-8I3; SPS 8I3; | ||
| SMILES | CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C | ||
| Chemical Name | |||
| Formula | C14H11NO3 | M. Wt | 241.24 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BVT948 is a protein tyrosine phosphatases (PTP) inhibitor (IC50 = 0.09 - 1.7 μM). BVT948 inhibits NF-κB activation by suppressing IκBα degradation and the nuclear translocation of NF-κB in TPA-treated MCF-7 cells. BVT948 didn’t block TPA-induced AP-1 activation in MCF-7 cells. BVT948 blocks MMP-9 expression of breast cancer cells by inhibiting the TPA-stimulated NF-κB pathway. | ||
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