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P glycoprotein

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P glycoprotein

Chemical Structure Cat. No. Product Name CAS No.
AZD-5672 Chemical Structure
 BCP48543 AZD-5672 780750-65-4
AZD-5672 is an orally active, potent, selective CCR5 antagonist. AZD-5672 shows moderate activity against the hERG ion channel. AZD5672 is used for the research of rheumatoid arthritis.
Encequidar Chemical Structure
 BCP25240 Encequidar 849675-66-7
Encequidar (HM30181) is a potent and selective inhibitor of P-glycoprotein.
Encequidar mesylate Chemical Structure
 BCP33772 Encequidar mesylate 849675-87-2
Encequidar mesylate (HM30181 mesylate) is a competitive and potent P-glycoprotein inhibitor.
Talinolol Chemical Structure
 BCP30483 Talinolol 57460-41-0
Talinolol is a beta(1)-adrenergic receptor antagonist and a probe drug for P-glycoprotein (P-gp) activity in humans.
Genz-123346 Chemical Structure
 BCP11811 Genz-123346 491833-30-8
Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity.
Cabazitaxel Chemical Structure
 BCP27641 Cabazitaxel 183133-96-2
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
BAL27862 Chemical Structure
 BCP16476 BAL27862 798577-91-0
BAL27862 is a a novel synthetic potent inhibitor of tubulin polymerization that induces cancer cell death. BAL27862 is a novel microtubule-destabilizing drug that is currently undergoing phase I clinical evaluation as the prodrug BAL101553. BAL27862 elicits a unique microtubule (MT) phenotype, distinct from paclitaxel, vinblastine and colchicine, has broad in vitro anti-proliferative activity against a diverse range of human tumor lines (low nM IC50s) and induces significant antitumor responses in a range
Piperine Chemical Structure
 BCP18901 Piperine 94-62-2
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
Tariquidar methanesulfonate, hydrate Chemical Structure
 BCP18814 Tariquidar methanesulfonate, hydrate 625375-83-9
Tariquidar methanesulfonate, hydrate is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
LY335979 Chemical Structure
 BCP27664 LY335979 167354-41-8
Zosuquidar (LY335979) is a potent negative modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
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