Rosiptor acetate
| CAS No. | 782487-29-0 | Cat. No. | BCP24919 |
| Name | Rosiptor acetate | ||
| Synonyms | AQX-1125 acetate;AQX1125 acetate;AQX 1125 acetate; | ||
| Formula | C22H39NO4 | M. Wt | 381.56 |
| Description | Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases. | ||
| Related Products | 782487-28-9（Rosiptor） | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphatase | ||
Structure
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