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Beta secretase

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Beta secretase

Chemical Structure Cat. No. Product Name CAS No.
Umibecestat HCl Chemical Structure
 BCP48028 Umibecestat HCl 2365306-62-1
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease.
MK-8931 Chemical Structure
 BCP46708 MK-8931 1613380-81-6
MK-8931 is a small-molecule inhibitor of BACE1 and BACE2.
Elenbecestat Chemical Structure
 BCP39709 Elenbecestat 1388651-30-6
Elenbecestat is a novel, potent and orally bioavailable BACE1 inhibitor for the treatment of Alzheimer's disease (AD), which demonstrates prolonged reductions in plasma beta-amyloid levels after single dosing.
Atabecestat Chemical Structure
 BCP25878 Atabecestat 1200493-78-2
Atabecestat, also known as JNJ-54861911, is a β-site amyloid presursor protein cleaving enzyme 1 (BACE1), an enzyme whose buildup is implicated in Alzheimer’s disease. JNJ-54861911 was found to inhibit BACE1 with approximately 2,600 nM affinity to 1 nM affinity.
Aloeresin D Chemical Structure
 BCP32579 Aloeresin D 105317-67-7
Aloeresin D is isolated and purified from the herbs of Aloe arborescens Mill.
beta-Secretase Inhibitor IV Chemical Structure
 BCP31596 beta-Secretase Inhibitor IV 797035-11-1
beta-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
NB-360 HCl Chemical Structure
 BCP30332 NB-360 HCl 1262855-97-9
NB-360 is a potent and brain penetrable BACE-1 inhibitor.
AZD3839 Chemical Structure
 BCP13212 AZD3839 1227163-56-5
AZD3839, with the potential to treat Alzheimer’s disease, was reported as a selective BACE1 inhibitor (IC50=4.8μM) for which concentration-dependent lowering of Ab peptides in cellular systems and three pre-clinical species were demonstrated.
Umibecestat Chemical Structure
 BCP30325 Umibecestat 1387560-01-1
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease.
RG7129 Chemical Structure
 BCP23733 RG7129 1310347-50-2
RG7129 is a potent BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM).
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