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PI3K/Akt/mTOR

Chemical Structure Cat. No. Product Name CAS No.
Nab-sirolimus Chemical Structure
 BCP49207 Nab-sirolimus 1402453-65-9
Nab-sirolimus is a nanoparticle albumin-bound mTOR inhibitor that has yielded significantly higher levels of tumor accumulation, mTOR target suppression, and anti-tumor activity.
PXL-770 Chemical Structure
 BCP49199 PXL-770 1523493-53-9
PXL 770 is an orally active, small molecule, selective and direct AMP-activated protein kinase (AMPK) activator.
Solenopsin HCl Chemical Structure
 BCP49141 Solenopsin HCl 137119-46-1
Solenopsin is an inhibitor of Akt.
KU59403 Chemical Structure
 BCP28847 KU59403 845932-30-1
KU 59403 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively.
SR13668 Chemical Structure
 BCP24033 SR13668 637774-61-9
SR13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities.
AZD 3147 Chemical Structure
 BCP24240 AZD 3147 1101810-02-9
AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K.
GSK2292767 Chemical Structure
 BCP24323 GSK2292767 1254036-66-2
GSK2292767 is a potent and selective PI3Kδ inhibitor.
Umbralisib sulfate Chemical Structure
 BCP24681 Umbralisib sulfate 1532533-75-7
Umbralisib sulfate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively.
Umbralisib R-enantiomer Chemical Structure
 BCP24683 Umbralisib R-enantiomer 1532533-69-9
Umbralisib R-enantiomer is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.
Umbralisib tosylate Chemical Structure
 BCP24684 Umbralisib tosylate 1532533-72-4
Umbralisib tosylate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib tosylate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib tosylate can be used for haematological malignancies reseach.
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