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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Ammonia Series
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- Saccharide
- Azaindole
- Indole Series
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- Heterocyclic Series
- Benzene Series
- Pyridine Series
Raw Materials
IAP
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP31134 | Embelin New | 550-24-3 | |
Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.
|
BCP28730 | ASTX-660 | 1799328-86-1 | |
ASTX660 is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).
|
BCP04668 | AT406 | 1071992-99-8 | |
AT-406 is an orally bioavailable potent IAP of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.
|
BCP19296 | MX69 | 1005264-47-0 | |
MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
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BCP16589 | SM-164 | 957135-43-2 | |
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein and binds to cIAP-1 and cIAP-2 proteins. It is developed as an anticancer agent. It plays its antitumor roles through inducing degradation of cellular inhibitor of apoptosis protein (cIAP)-1/2, antagonizing X-linked inhibitor of apoptosis protein (XIAP) and inducing TNFα–dependent apoptosis in tumor cells. SM-164 is a bivalent mimetic containing two SM-122 analogues. It binds to cIAP-1 protein containing bothBIR2 and BIR3 domains, cIAP-2 BIR3 protein and XIAP protein containing both BIR2 and BIR3 domains.
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BCP20145 | AZD5582 | 1258392-53-8 | |
AZD5582 is a novel class of dimeric Smac mimetics as potent IAP antagonist; binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively).
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BCP08767 | GDC-0152 | 873652-48-3 | |
GDC-0152 is a potent inhibitor of IAPs; binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K(i) values of 28, 14, 17, and 43 nM, respectively.
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BCP10549 | BV6 | 1001600-56-1 | |
BV6 is a small-molecule Smac mimetic, which antagonizes IAP and induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2.
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BCP08607 | Birinapant | 1260251-31-7 | |
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
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BCP07833 | LCL161 New | 1005342-46-0 | |
LCL161 is an oral small molecule antagonist of Inhibitor of Apoptosis Proteins (IAPs) that sensitizes a subset of tumors from diverse lineages to treatment with cytotoxic therapies.
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