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Wnt

Chemical Structure Cat. No. Product Name CAS No.
LP-922056 Chemical Structure
 BCP28623 LP-922056 1365060-22-5
LP-922056 is a Notum pectinacetylesterase inhibitor which activates wnt signalling. LP-922056 increases cortical bone thickness in a mouse model of bone growth.
ABC99 Chemical Structure
 BCP47152 ABC99 2331255-53-7
ABC99 is an irreversible, potent and selective inhibitor against the serine hydrolase activity of the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM.
Box5 Chemical Structure
 BCP46893 Box5 881188-48-3
Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.
HLY78 Chemical Structure
 BCP45530 HLY78 854847-61-3
HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction.
FIDAS-3 Chemical Structure
 BCP45452 FIDAS-3 1266684-01-8
FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A).
Dalosirvat Chemical Structure
 BCP44837 Dalosirvat 1360540-81-3
Dalosirvat is a topical Wnt pathway activator for the treatment of androgenetic alopecia (AGA).
FOXY-5 Chemical Structure
 BCP43701 FOXY-5 881188-51-8
FOXY-5 is a Wnt5a peptide mimetic. It has been undergoing clinical trials for the treatment of prostate cancer, colorectal cancer, metastatic colon cancer, metastatic breast cancer, and metastatic prostate cancer.
Heparitin, sulfate Chemical Structure
 BCP43695 Heparitin, sulfate 9050-30-0
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
Adavivint HCl Chemical Structure
 BCP42884 Adavivint HCl AdavivintHCl
Adavivint is a small-molecule inhibitor of the Wnt pathway which is being investigated as a potential disease modifying agent for the treatment of osteoarthritis of the knee.
IWP-O1 Chemical Structure
 BCP41115 IWP-O1 2074607-48-8
IWP-O1 is a potent porcupine inhibitor that blocks Wnt signaling in L-Wnt-STF cells with EC50 value of 80 pM. IWP-O1 can affect differentiation of hESC.
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