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Histone Methyltransferase

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Histone Methyltransferase

Chemical Structure Cat. No. Product Name CAS No.
MS023 dihydrochloride Chemical Structure
 BCP49591 MS023 dihydrochloride 1992047-64-9
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.
Pociredir Chemical Structure
 BCP49202 Pociredir 2490674-02-5
Pociredir is an embryonic ectoderm development (EED) protein inhibitor. Pociredir can be used for the research of inflammatory or hemoglobinopathies, such as sickle cell disease.
TNG908 Chemical Structure
 BCP49197 TNG908 2760481-53-4
TNG908 is a MTAP-cooperative PRMT5 inhibitor that can pass through the blood-brain barrier.
WDR5-IN-1 Chemical Structure
 BCP49073 WDR5-IN-1 2408842-51-1
WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of <0.02 nM.
MM-401 Chemical Structure
 BCP25182 MM-401 1442106-10-6
MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
AM-9747 Chemical Structure
 BCP46595 AM-9747 2691869-82-4
AM-9747 is a MTA Cooperative PRMT5 Inhibitor.
MRTX1719 HCl Chemical Structure
 BCP46040 MRTX1719 HCl MRTX1719HCl
MRTX-1719 is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAPDEL SDMA cells.
EZM0414 Chemical Structure
 BCP45983 EZM0414 2411748-50-8
EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay).
PF-06821497 Chemical Structure
 BCP45826 PF-06821497 1844849-10-0
EZH2 Inhibitor PF-06821497 is an orally available selective inhibitor of the histone lysine methyltransferase (HMT) enhancer of zeste homolog 2 (EZH2), with potential antineoplastic activity.
PRMT5-IN-3 Chemical Structure
 BCP45773 PRMT5-IN-3 2159123-14-3
PRMT5-IN-3 is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents.
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