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Raw Materials
FLT3
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP49212 | Tuspetinib hydrate New | 2758339-04-5 | |
Tuspetinib (HM43239) is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells.
|
BCP48923 | HPK1-IN-2 New | 2056122-11-1 | |
HPK1-IN-2 is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1), Lck and Flt3. HPK1-IN-2 exhibits antitumor activity.
|
BCP48905 | FLT3-IN-16 New | 298207-49-5 | |
FLT3-IN-16 is a inhibitor of Influenza Virus Polymerase.
|
BCP46930 | KG5 New | 877874-85-6 | |
KG 5 is an orally available PDGFRß and B-Raf allosteric inhibitor.
|
BCP46381 | MAX-40279 hemifumarate New | 2388506-43-0 | |
MAX-40279 hemifumarate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase.
|
BCP46003 | MAX-40279 hemiadipate New | 2388506-44-1 | |
MAX-40279 hemiadipate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase.
|
BCP46002 | MAX-40279 New | 2070931-57-4 | |
MAX-40279 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity.
|
BCP45355 | FLT3-IN-3 New | 2229050-90-0 | |
FLT3-IN-3 is a potent and selective FLT3 inhibitor.
|
BCP40967 | HM43239 New | 2569527-64-4 | |
HM43239 is an orally active small molecule inhibitor of FLT3 that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations.
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BCP42651 | SB1317 New | 1204918-72-8 | |
SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.
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