Classified by application
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Signaling Pathways
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- Epigenetics
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GPCR/G Protein
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Neuro Signaling Pathway
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Protease/Metabolic Enzyme
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Research Areas
- Metabolic Disease
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Ammonia Series
- Azaindazole
- Pyridazine Series
- Nucleoside Series
- Quinazoline
- Pyrazole Series
- Boric acid
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- Pyrrole Series
- Thiophene Series
- Saccharide
- Azaindole
- Indole Series
- Piperidine Series
- Indazole Series
- Heterocyclic Series
- Benzene Series
- Pyridine Series
Raw Materials
mAChR
Chemical Structure | Cat. No. | Product Name | CAS No. |
---|
BCP23970 | ARL 14495 New | 123319-03-9 | |
ARL 14495 is a rigid M1/M3 muscarinic agonist affecting acetylcholine activity, used often in the treatment of Alzheimer’s disease.
|
BCP24273 | Otenzepad New | 100158-38-1 | |
Otenzepad is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.
|
BCP49007 | 4-DAMP New | 1952-15-4 | |
4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor.
|
BCP48520 | Emraclidine New | 2170722-84-4 | |
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator.
|
BCP47001 | VU0467154 New | 1451993-15-9 | |
VU0467154 is a potent and selective M4 PAM. VU0467154 exhibits robust APD-like and cognitive enhancing activity in rodents. Selective M4 PAMs could provide a therapeutic strategy for the treatment of HD.
|
BCP46891 | Deschloroclozapine New | 1977-07-7 | |
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
|
BCP44336 | Diphemanil Methylsulfate New | 62-97-5 | |
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic.It binds muscarinic acetycholine receptors (mAchR).
|
BCP44037 | Nebracetam New | 116041-13-5 | |
Nebracetam, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration.
|
BCP43183 | Sofpironium bromide New | 1628106-94-4 | |
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.
|
BCP43186 | VU0453595 New | 1432436-13-9 | |
VU0453595 is a novel M1 positive allosteric modulator (PAM), potential in schizophrenia.
|