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DYRK

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DYRK

Chemical Structure Cat. No. Product Name CAS No.
ID-8 Chemical Structure
 BCP27795 ID-8 147591-46-6
ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs.
GNF2133 HCl Chemical Structure
 BCP45493 GNF2133 HCl 2561414-57-9
GNF2133 hydrochloride is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively.
AZ Dyrk1B 33 Chemical Structure
 BCP41848 AZ Dyrk1B 33 1679330-37-0
AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor.
LDN-192960 dihydrochloride Chemical Structure
 BCP37917 LDN-192960 dihydrochloride 2309172-48-1
LDN-192960 is a potent and selective inhibitor of haspin.
tBID Chemical Structure
 BCP36081 tBID 1639895-85-4
tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of  0.33 µM.
GNF4877 Chemical Structure
 BCP31624 GNF4877 2041073-22-5
GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM.
Protein kinase inhibitors 1 Chemical Structure
 BCP30842 Protein kinase inhibitors 1 1365986-44-2
Protein Kinase Inhibitors 1 is a HIPK2 inhibitor with IC50 of 74 nM and Kd of 9.5 nM.
AZ191 Chemical Structure
 BCP12820 AZ191 1594092-37-1
AZ191 is a potent small molecule inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM; selective for DYRK1B over both DYRK1A and DYRK2.
Garmin Chemical Structure
 BCP09794 Garmin 442-51-3
Harmine, a tricyclic b-carboline alkaloid that was originally isolated from seeds of Peganum harmala, has been reported to possess anxiolytic, behavioral effects.
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