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Raw Materials
IRE1
Chemical Structure | Cat. No. | Product Name | CAS No. |
---|
BCP45136 | IXA4 New | 1185329-96-7 | |
IXA4 is a highly selective, non-toxic IRE1/XBP1s activator.
|
BCP36235 | MKC8866 New | 1338934-59-0 | |
MKC8866, also known as IRE1-IN-8866, is an inhibitor of IRE1 RNase activity.
|
BCP40087 | Kira8 New | 1630086-20-2 | |
Kira8 is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
|
BCP20799 | MKC3946 | 1093119-54-0 | |
MKC3946 is a potent and soluble IRE1α inhibitor. MKC-3946 blocks XBP1 mRNA splicing and exhibits cytotoxicity against AML cells.
|
BCP26100 | KIRA6 | 1589527-65-0 | |
KIRA6 allosterically inhibits IRE1α RNase kinase activity with an IC50 of 0.6 µM.
|
BCP09071 | APY29 | 1216665-49-4 | |
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
|
BCP16458 | STF 083010 | 307543-71-1 | |
STF-083010 is a novel small-molecule inhibitor of Ire1α; inhibits Ire1 endonuclease activity, without affecting its kinase activity after endoplasmic reticulum stress both in vitro and in vivo.
|
BCP21011 | 4μ8C | 14003-96-4 | |
4μ8C is selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
|