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LIMK

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LIMK

Chemical Structure Cat. No. Product Name CAS No.
R-10015 Chemical Structure
 BCP37585 R-10015 2097938-51-5
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1.
TH263 Chemical Structure
 BCP32731 TH263 313520-94-4
TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257.
TH-257 Chemical Structure
 BCP31775 TH-257 2244678-29-1
TH257 is a Potent and selective allosteric LIMK 1/2 inhibitor.
LX7101 Chemical Structure
 BCP02298 LX7101 1192189-69-7
LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM.
BMS-3 Chemical Structure
 BCP17224 BMS-3 1338247-30-5
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
LIMKI-3 Chemical Structure
 BCP17223 LIMKI-3 1338247-35-0
LIMKI-3 (BMS-5) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
T56-LIMKi Chemical Structure
 BCP28984 T56-LIMKi 924473-59-6
T56-LIMKi, also known as T5601640, is a selective inhibitor of LIMK2 that reduces phosphorylated cofilin and inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM.
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