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NF κB

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NF κB

Chemical Structure Cat. No. Product Name CAS No.
Edasalonexent Chemical Structure
 BCP25138 Edasalonexent 1204317-86-1
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.
Vamorolone Chemical Structure
 BCP47443 Vamorolone 13209-41-1
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.
Sodium salicylate Chemical Structure
 BCP47031 Sodium salicylate 54-21-7
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
Sappanone A Chemical Structure
 BCP46467 Sappanone A 102067-84-5
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.
SM-7368 Chemical Structure
 BCP46452 SM-7368 380623-76-7
SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.
NDMC101 Chemical Structure
 BCP46451 NDMC101 1308631-40-4
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.
WAY-204688 Chemical Structure
 BCP46376 WAY-204688 796854-35-8
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAECT-1 cells).
SP-8356 Chemical Structure
 BCP45208 SP-8356 1454885-45-0
SP-8356 an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor.
N-Acetyl-cysteine Chemical Structure
 BCP45078 N-Acetyl-cysteine 616-91-1
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results. Acetylcysteine was granted FDA approval on 14 September 1963.
B022 Chemical Structure
 BCP45058 B022 1202764-53-1
B022 is a novel inhibitor of NF-kappaB-inducing kinase (NIK), protecting liver from toxin-induced inflammation, oxidative stress, and injury.
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