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PAK

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PAK

Chemical Structure Cat. No. Product Name CAS No.
PF-03758309 hydrochloride salt Chemical Structure
 BCP24749 PF-03758309 hydrochloride salt 1279034-84-2
PF-3758309 hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM).
LCH-7749944 Chemical Structure
 BCP46494 LCH-7749944 796888-12-5
LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.
IPA-3 Chemical Structure
 BCP42390 IPA-3 42521-82-4
IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
beta-Elemene Chemical Structure
 BCP31326 beta-Elemene 33880-83-0
beta-Elemene is an inhibitor of Pak1 activation, and an anti-cancer ingredient isolated from the Chinese traditional herb Curcuma wenyujin.
FTY720 Acetic Acid Hydrochloride Chemical Structure
 BCP31238 FTY720 Acetic Acid Hydrochloride 1346598-36-4
FTY720 is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.
Padnarsertib Chemical Structure
 BCP10637 Padnarsertib 1643913-93-2
Padnarsertib is an orally bioavailable inhibitor of both the serine/threonine kinase P21-activated kinase 4 (PAK4) and the nicotinamide adenine dinucleotide (NAD)-synthesizing enzyme nicotinamide phosphoribosyltransferase (NAMPT; NAMPRTase), with potential antineoplastic activity.
NVS-PAK1-1 Chemical Structure
 BCP29548 NVS-PAK1-1 1783816-74-9
NVS-PAK1-1 is a a specific allosteric PAK1 inhibitor.
FRAX597 Chemical Structure
 BCP12649 FRAX597 1286739-19-2
FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
FRAX-1036 Chemical Structure
 BCP20209 FRAX-1036 1432908-05-8
FRAX1036 is a novel ATP-competitive small molecule inhibitor of group I p21-activated Kinases (PAKs).
5-Aminosalicylic acid Chemical Structure
 BCP05326 5-Aminosalicylic acid 89-57-6
5-Aminosalicylic acid is an anti-inflammatory compound.
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