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Signaling Pathways
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- Epigenetics
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GPCR/G Protein
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Neuro Signaling Pathway
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Protease/Metabolic Enzyme
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Research Areas
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Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Ammonia Series
- Azaindazole
- Pyridazine Series
- Nucleoside Series
- Quinazoline
- Pyrazole Series
- Boric acid
- Pyrimidine Series
- Quinoline Series
- Pyrrole Series
- Thiophene Series
- Saccharide
- Azaindole
- Indole Series
- Piperidine Series
- Indazole Series
- Heterocyclic Series
- Benzene Series
- Pyridine Series
Raw Materials
CRM1
Chemical Structure | Cat. No. | Product Name | CAS No. |
---|
BCP35974 | Leptomycin B New | 87081-35-4 | |
Leptomycin B is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
|
BCP32614 | Selinexor E-isomer New | 1421923-86-5 | |
Selinexor trans-isomer is a trans-isomer of Selinexor or KPT-330, which is a CRM1-selective inhibitor of nuclear export.
|
BCP24993 | Eltanexor New | 1642300-52-4 | |
Eltanexor(KPT-8602) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
|
BCP13030 | Piperlongumine | 20069-09-4 | |
Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
|
BCP11733 | Verdinexor | 1392136-43-4 | |
Verdinexor(KPT-335) is a novel, orally bioavailable selective inhibitor of nuclear export (SINE), inhibits nuclear export protein Exportin 1(XPO1/CRM1) against canine tumor cell lines; also reduce influenza virus replication in vitro and in vivo.
|
BCP09428 | KPT-276 | 1421919-75-6 | |
KPT-276 is an orally bioavailable selective CRM1 inhibitor.
|
BCP08966 | Selinexor New | 1393477-72-9 | |
KPT-330 is an orally bioavailable selective CRM1 inhibitor.
|
BCP08195 | KPT-185 | 1333151-73-7 | |
KPT-185 is a selective CRM1 inhibitor.
|