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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
ACE-1334 Chemical Structure
 BCP49508 ACE-1334 ACE-1334
ACE-1334 is an Acceleron-discovered, TGF-beta superfamily-based ligand trap designed to bind and inhibit TGF-beta 1 and 3 ligands but not TGF-beta 2.
Zilurgisertib Chemical Structure
 BCP49234 Zilurgisertib 2173389-57-4
Zilurgisertib is a selective ALK 2 inhibitor for researching diseases such as cancer.
Zilurgisertib fumarate dihydrate Chemical Structure
 BCP49233 Zilurgisertib fumarate dihydrate 2173390-29-7
Zilurgisertib is a serine/threonine kinase inhibitor.
PD 161570 Chemical Structure
 BCP24138 PD 161570 192705-80-9
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
Halofuginone hydrobromide Chemical Structure
 BCP24882 Halofuginone hydrobromide 17395-31-2
Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities.
WAY-354831 Chemical Structure
 BCP48904 WAY-354831 330572-32-2
WAY-354831 exhibits antibacterial activity.
HA-100 dihydrochloride Chemical Structure
 BCP48930 HA-100 dihydrochloride 210297-47-5
HA-100 dihydrochloride is a protein kinase inhibitor, inhibiting superoxide release from human neutrophils (PMN).
GSK180736A Chemical Structure
 BCP25022 GSK180736A 817194-38-0
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
H-1152 Dihydrochloride Chemical Structure
 BCP25257 H-1152 Dihydrochloride 871543-07-6
H-1152 dihydrochloride is an isoquinolinesulfonamide derivative that is a membrane-permeable inhibitor of Rho-kinase but poor inhibitor of other serine/threonine kinases.
Bisindoylmaleimide X HCl Chemical Structure
 BCP25394 Bisindoylmaleimide X HCl 145317-11-9
Bisindolylmaleimide X hydrochloride is a potent and selective protein kinase C (PKC) inhibitor.
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