Raphin1 acetate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2242616-04-0 | Cat. No. | BCP48942 |
| Related Products | 2022961-17-5（Raphin1） | ||
| Name | Raphin1 acetate | ||
| Synonyms | |||
| SMILES | CC(=O)O.C1=CC(=C(C(=C1)Cl)Cl)C=NN=C(N)N | ||
| Chemical Name | |||
| Formula | C10H12Cl2N4O2 | M. Wt | 291.13 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease. | ||
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