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Trk Receptor

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Trk Receptor

Chemical Structure Cat. No. Product Name CAS No.
AZD-7451 Chemical Structure
 BCP44112 AZD-7451 1079274-94-4
AZD7451 is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity
CH7057288 Chemical Structure
 BCP33760 CH7057288 2095616-82-1
CH7057288 is a potent and selective TRK inhibitor.
ONO7475 Chemical Structure
 BCP33232 ONO7475 1646839-59-9
ONO-7475 is a potent and orally active Axl/Mer inhibitor. ONO-7475 targets and binds to both Axl and Mer, and prevents their activity.
LOXO-101 HCl salt Chemical Structure
 BCP30585 LOXO-101 HCl salt 1919868-83-9
LOXO-101 is an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity.
LOXO195 R racemic Chemical Structure
 BCP30220 LOXO195 R racemic 1350884-56-8
(6RS)-LOXO-195 is a potent and selective Trk tyrosine kinase inhibitor.The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.
LOXO195 RS-isomer Chemical Structure
 BCP30219 LOXO195 RS-isomer 2097002-59-8
The RS-isomer of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.
LM22B-10 Chemical Structure
 BCP30139 LM22B-10 342777-54-2
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
PD90780 Chemical Structure
 BCP16228 PD90780 77422-99-2
PD90780 is a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR.
AZ-23 Chemical Structure
 BCP01916 AZ-23 915720-21-7
AZ-23 is a potent and selective tyrosine kinase (Trk) inhibitor having potential for therapeutic utility in neuroblastoma and multiple other cancers.
PF-06273340 Chemical Structure
 BCP29619 PF-06273340 1402438-74-7
PF-06273340 is a potent, selective, and peripherally restricted Pan-Trk Inhibitor with an excellent LipE profile (IC50 value: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM).
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