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DNA Alkylator/Crosslinker

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DNA Alkylator/Crosslinker

Chemical Structure Cat. No. Product Name CAS No.
Phosphoramide mustard Chemical Structure
 BCP48451 Phosphoramide mustard 10159-53-2
Phosphoramide mustard is a nitrogen mustard and a phosphorodiamide.Phosphoramide mustard is the major metabolite for Cyclophosphamide, with anticancer activitiy. Phosphoramide mustard induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response.
SG2057 Chemical Structure
 BCP46387 SG2057 260417-62-7
SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence.
SG3199 Chemical Structure
 BCP46386 SG3199 1595275-71-0
SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines.
D-scyllo-Inositol, 1-azido-1-deoxy-2,3,4,5,6-pentakis-O-(phenylmethyl)- Chemical Structure
 BCP34936 D-scyllo-Inositol, 1-azido-1-deoxy-2,3,4,5,6-pentakis-O-(phenylmethyl)- 868550-22-5
1-Amino-1-desoxy-scyllo-inosit Chemical Structure
 BCP34937 1-Amino-1-desoxy-scyllo-inosit 16051-25-5
Sarcolysin hydrochloride Chemical Structure
 BCP34935 Sarcolysin hydrochloride 1465-26-5
DL-Melphalan hydrochloride is a nitrogen mustard and alkylating agent that has been studied for use in multiple myeloma therapy.
Melphalan Hydrochloride Chemical Structure
 BCP33593 Melphalan Hydrochloride 3223-07-2
Melphalan is an orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
Treosulfa Chemical Structure
 BCP31509 Treosulfa 299-75-2
Treosulfan is an alkylating agent with activity in ovarian cancer and other solid tumor types.
Cyano Temozolomide Chemical Structure
 BCP22927 Cyano Temozolomide 287964-59-4
Temozolomide is an oral DNA alkylating agent used to treat some brain cancers.
Evofosfamide Chemical Structure
 BCP06074 Evofosfamide 918633-87-1
Evofosfamide is a potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes; inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively; active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.
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