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RIP

Chemical Structure Cat. No. Product Name CAS No.
SAR-443820 Chemical Structure
 BCP49450 SAR-443820 SAR-443820
SAR443820 is a central nervous system (CNS)-penetrant small molecule inhibitor of RIPK1.
Eclitasertib Chemical Structure
 BCP48186 Eclitasertib 2125450-76-0
Eclitasertib is a receptor-interacting serine/ threonine protein (RIP-1) kinase inhibitor.
Necrostatin-34 Chemical Structure
 BCP44627 Necrostatin-34 375835-43-1
Necrostatin-34, a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
RIPA-56 Chemical Structure
 BCP44340 RIPA-56 1956370-21-0
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.
GSK840 Chemical Structure
 BCP43841 GSK840 2361146-30-5
GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM.
ICCB-19 HCl Chemical Structure
 BCP43518 ICCB-19 HCl 1803605-68-6
ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively.
GSK-963 Chemical Structure
 BCP37994 GSK-963 2049868-46-2
GSK-963 is a potent and selective inhibitor of RIP1 kinase.
GSK962 Chemical Structure
 BCP37995 GSK962 2049872-86-6
GSK962 is a negative control for GSK'963, a highly potent and selective RIP1 inhibitor.
GSK-843 Chemical Structure
 BCP37845 GSK-843 1601496-05-2
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM.
RIPK1-IN-4 Chemical Structure
 BCP35149 RIPK1-IN-4 1481641-08-0
RIPK1-IN-4 is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase.
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