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cFMS

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cFMS

Chemical Structure Cat. No. Product Name CAS No.
c-Fms-IN-12 Chemical Structure
 BCP44099 c-Fms-IN-12 1313407-95-2
c-Fms-IN-12 is a c-Fms inhibitor.
Vimseltinib Chemical Structure
 BCP44095 Vimseltinib 1628606-05-2
Vimseltinib, also known as DCC-3014, is a potent and orally active inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities.
AZD7507 Chemical Structure
 BCP36143 AZD7507 1041852-85-0
AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.
cFMS Receptor Inhibitor II Chemical Structure
 BCP31859 cFMS Receptor Inhibitor II 959860-85-6
cFMS Receptor Inhibitor II is a cFMS inhibitor.
PLX5622 Chemical Structure
 BCP31350 PLX5622 1303420-67-8
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals.
JNJ-28312141 Chemical Structure
 BCP28018 JNJ-28312141 885692-52-4
JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.
PLX647 Chemical Structure
 BCP15182 PLX647 873786-09-5
PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively.
c-FMS inhibitor Chemical Structure
 BCP21866 c-FMS inhibitor 885704-21-2
c-FMS inhibitor is a potent, orally active and small-molecule inhibitor of FMS kinase with IC50 value of 0.8 nM.
Edicotinib Chemical Structure
 BCP25086 Edicotinib 1142363-52-7
Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity.
Ki20227(+/-) Chemical Structure
 BCP01956 Ki20227(+/-) 623142-96-1
Ki20227 is a c-Fms tyrosine kinase inhibitor.
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