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LRRK2

Chemical Structure Cat. No. Product Name CAS No.
CZC 54252 hydrochloride Chemical Structure
 BCP47285 CZC 54252 hydrochloride 1784253-05-9
CZC 54252 hydrochloride is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM).
MLi-2 Chemical Structure
 BCP35880 MLi-2 1627091-47-7
MLi-2 is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinson’s disease.
PFE-360 Chemical Structure
 BCP34885 PFE-360 1527475-61-1
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase.
PF-06454589 Chemical Structure
 BCP30270 PF-06454589 1527473-30-8
PF-06454589 is a potent and selective LRRK2 inhibitor.
GNE-0877 Chemical Structure
 BCP09654 GNE-0877 1374828-69-9
GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.
CZC-54252 Chemical Structure
 BCP15148 CZC-54252 1191911-27-9
CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively.
CZC-25146.HCl Chemical Structure
 BCP09557 CZC-25146.HCl 1330003-04-7
CZC-25146 Hcl is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
CZC 25146 Chemical Structure
 BCP14116 CZC 25146 1191911-26-8
CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.
HG-10-102-01 Chemical Structure
 BCP09106 HG-10-102-01 1351758-81-0
HG-10-102-01 is a brain penetrant, potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC50 for LRRK2-wild-type ~20.3 nM and LRRK2-[G2019S] ~3.2 nM).
GNE9605 Chemical Structure
 BCP10209 GNE9605 1536200-31-3
GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM.
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