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RO4929097 Chemical Structure

RO4929097

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02623CAS No. ：847925-91-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 847925-91-1 Cat. No. BCP02623
Name RO4929097
Synonyms R4733; R 4733; R-4733;RO-4929097;RO 4929097; RO04929097; RO-04929097; RO 04929097;
SMILES O=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O
Chemical Name
Formula C22H20F5N3O3 M. Wt 469.4
Purity 98% Storage Store at 4-8°C
Description RO4929097 decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells with EC50 of 14 nM. RO4929097 strongly inhibits Notch processing with EC50 of 5 nM in the Notch cell-based reporter assay. The potency of RO4929097 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity observed with respect to 75 other proteins of various types including receptors, ion channels, and enzymes (CEREP panel).
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HPLC H-NMR
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