RO4929097
| CAS No. | 847925-91-1 | Cat. No. | BCP02623 |
| Name | RO4929097 | ||
| Synonyms | R4733; R 4733; R-4733;RO-4929097;RO 4929097; RO04929097; RO-04929097; RO 04929097; | ||
| Formula | C22H20F5N3O3 | M. Wt | 469.4 |
| Description | RO4929097 decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells with EC50 of 14 nM. RO4929097 strongly inhibits Notch processing with EC50 of 5 nM in the Notch cell-based reporter assay. The potency of RO4929097 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity observed with respect to 75 other proteins of various types including receptors, ion channels, and enzymes (CEREP panel). | ||
| Pathways | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| Targets | Gamma secretase | ||
Structure
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