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CAS No. | 209986-17-4 | Cat. No. | BCP02178 |
Name | γ-Secretase Inhibitor XXI | ||
Synonyms | Compound E;DuPont E;g-Secretase Inhibitor XXI;gamma-Secretase Inhibitor XXI; | ||
SMILES | CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F | ||
Chemical Name | |||
Formula | C27H24F2N4O3 | M. Wt | 490.5 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Compound E is a cell-permeable inhibitor of γ-secretase (GSI), which is a multifunctional transmembrane protein complex enzymatically catalyzing the cleavage of single-pass transmembrane proteins. Compound E can inhibit Notch processing (IC50 = 2.2 nM in SupT1 cells) and β-ammyloid production in cell culture (IC50 = 0.3 nM). |
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