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γ-Secretase Inhibitor XXI Chemical Structure

γ-Secretase Inhibitor XXI

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02178CAS No. :209986-17-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 209986-17-4 Cat. No. BCP02178
Name γ-Secretase Inhibitor XXI
Synonyms Compound E;DuPont E;g-Secretase Inhibitor XXI;gamma-Secretase Inhibitor XXI;
SMILES CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
Chemical Name
Formula C27H24F2N4O3 M. Wt 490.5
Purity 98% Storage Store at 4-8°C
Description Compound E is a cell-permeable inhibitor of γ-secretase (GSI), which is a multifunctional transmembrane protein complex enzymatically catalyzing the cleavage of single-pass transmembrane proteins. Compound E can inhibit Notch processing (IC50 = 2.2 nM in SupT1 cells) and β-ammyloid production in cell culture (IC50 = 0.3 nM).
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