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Camptothecin Chemical Structure

Camptothecin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02857CAS No. :7689-03-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 7689-03-4 Cat. No. BCP02857
Name Camptothecin
Synonyms Camptothecine (S,+);(S)-(+)-Camptothecin; d-Camptothecin; 20(S)-Camptothecine; (+)-Camptothecin; Camptothecine; CPT;
SMILES CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
Chemical Name
Formula C20H16N2O4 M. Wt 348.35
Purity 98% Storage Store at 4-8°C
Description Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
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