Bisantrene dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 71439-68-4 | Cat. No. | BCP46265 |
| Related Products | 78186-34-2（Bisantrene） | ||
| Name | Bisantrene dihydrochloride | ||
| Synonyms | Bisantrene HCl;CL-216942; CL216942; CL 216942; | ||
| SMILES | C1CN=C(N1)NN=CC2=C3C=CC=CC3=C(C4=CC=CC=C42)C=NNC5=NCCN5.Cl.Cl | ||
| Chemical Name | |||
| Formula | C22H24Cl2N8 | M. Wt | 471.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Bisantrene is topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. | ||
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