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BAY 41-2272 Chemical Structure

BAY 41-2272

Data Sheet For research use only. Not for human use.
Cat. No. :BCP16012CAS No. :256376-24-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 256376-24-6 Cat. No. BCP16012
Name BAY 41-2272
Synonyms BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272;
SMILES C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F
Chemical Name
Formula C20H17FN6 M. Wt 360.39
Purity 98% Storage Store at 4-8°C
Description BAY 41-2272 is a a soluble guanylate cyclase stimulator (sGC stimulator). BAY 41-2272 inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.2,3 BAY 41-2272 is effective in vivo. BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats.
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