BAY 41-2272
| CAS No. | 256376-24-6 | Cat. No. | BCP16012 |
| Name | BAY 41-2272 | ||
| Synonyms | BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272; | ||
| Formula | C20H17FN6 | M. Wt | 360.39 |
| Description | BAY 41-2272 is a a soluble guanylate cyclase stimulator (sGC stimulator). BAY 41-2272 inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.2,3 BAY 41-2272 is effective in vivo. BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Guanylate Cyclase | ||
Structure
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