CHIR-99021 trihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1782235-14-6 | Cat. No. | BCP26069 |
| Name | CHIR-99021 trihydrochloride | ||
| Synonyms | CT99021 trihydrochloride;CHIR-99021 3HCl; GSK 3 inhibitor XVI; GSK 3IXV; | ||
| SMILES | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl.Cl.Cl | ||
| Chemical Name | |||
| Formula | M. Wt | 574.72 | |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CHIR-99021 trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 trihydrochloride induces autophagy. | ||
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