Alsterpaullone New
Data Sheet
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| CAS No. | 237430-03-4 | Cat. No. | BCP33241 |
| Name | Alsterpaullone | ||
| Synonyms | 9-Nitropaullone; NSC 705701; NSC705701; NSC-705701; | ||
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-] | ||
| Chemical Name | |||
| Formula | C16H11N3O3 | M. Wt | 293.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the treatment of neurodegenerative and proliferative disorders. | ||
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