PFI-4 New
Data Sheet
For research use only. Not for human use.
Get Quotation Now Tel: 0086-17754423994 or orders@biochempartner.com
Real-Time Inquiry ×
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 900305-37-5 | Cat. No. | BCP23818 |
| Name | PFI-4 | ||
| Synonyms | PFI 4; PFI4; | ||
| SMILES | CN1C2=C(C=C(C(=C2)NC(=O)C3=CC=CC=C3OC)N4CCCC4)N(C1=O)C | ||
| Chemical Name | |||
| Formula | C21H24N4O3 | M. Wt | 380.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 = 80 nM. PFI-4 specifically binds to BRPF1B with a Kd =13 nM as determined by ITC. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. BRPF1 exists in 2 different isoforms: BRPF1A and BRPF1B. A residue insertion in the ZA loop of BRPF1A prevents binding to acetylated histone peptides. BRPF1A may act as dominant negative isoform of BRPF1 generated by alternative splicing. | ||
In the process of purchasing and using Biochempartner products, you can consult us if you have any problems: orders@biochempartner.com. We will try our best to solve all your doubts.
Recommend Products
More >
Tags:PFI-4 supplier,PFI-4 purchase,PFI-4 manufacturer,PFI-4 distributor,PFI-4 cost,PFI-4 buy,PFI-4 for sale