RVX297 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1044871-04-6 | Cat. No. | BCP43937 |
| Name | RVX297 | ||
| Synonyms | RVX 297; RVX-297; | ||
| SMILES | CC1=CC(=CC(=C1OCCN2CCCC2)C)C3=NC4=C(C(=CC(=C4)OC)OC)C(=O)N3 | ||
| Chemical Name | |||
| Formula | C24H29N3O4 | M. Wt | 423.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 is structurally related to the clinical compound RVX-208, currently undergoing phase III clinical trials for the treatment of cardiovascular diseases, but is distinctly different in its biological and pharmacokinetic profiles. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. Selective inhibition of either BD1 or BD2 can have significant implications on differential gene expression, which possibly can be further linked to the specific disease indication. | ||
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