NI-42 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1884640-99-6 | Cat. No. | BCP43848 |
| Name | NI-42 | ||
| Synonyms | NI 42; NI42; | ||
| SMILES | CC1=CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)C#N)N(C1=O)C | ||
| Chemical Name | |||
| Formula | C18H15N3O3S | M. Wt | 353.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NI-42 is a potent and selective BRPF1 in inhibitor with BRPF1 IC50 = 7.9 nM; LE: 0.45; LLE: 5.6. NI-42 is suitable for cellular and in vivo studies to explore the fundamental biology of these proteins. The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Evaluation of the BRPF family as a potential drug target is at an early stage although there is an emerging understanding of a role in acute myeloid leukemia (AML). | ||
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