Crenolanib besylate New
Data Sheet
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| CAS No. | 670220-93-6 | Cat. No. | BCP24113 |
| Name | Crenolanib besylate | ||
| Synonyms | Crenolanib besilate; CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; | ||
| SMILES | CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4.C1=CC=C(C=C1)S(=O)(=O)O | ||
| Chemical Name | |||
| Formula | C32H35N5O5S | M. Wt | 601.72 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Crenolanib Besylate is the besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types. | ||
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