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SIM010603 Chemical Structure

SIM010603

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP25213CAS No. ：1032265-67-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1032265-67-0 Cat. No. BCP25213
Name SIM010603
Synonyms SIM 010603; SIM-010603;
SMILES
Chemical Name
Formula C22H25FN4O2 M. Wt 396.46
Purity 98% Storage Store at 4-8°C
Description SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.
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