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CL2A-SN-38 Chemical Structure

CL2A-SN-38

Data Sheet For research use only. Not for human use.
Cat. No. :BCP32728CAS No. :1279680-68-0Purity:98%
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  • Publications Citing of Biochempartner's CL2A-SN-38
  • Chemical Properties&Biological Activity
CAS No. 1279680-68-0 Cat. No. BCP32728
Name CL2A-SN-38
Synonyms
SMILES O=C(O[C@](C1=C(CO2)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C1)=O)(CC)C2=O)OCC6=CC=C(NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CN9C(C=CC9=O)=O)CC8)=O)=C7)=O)=O)=O)C=C6
Chemical Name
Formula C73H97N11O22 M. Wt 1480.61
Purity 98% Storage Store at 4-8°C
Description CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond.
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