SG3199 New
Data Sheet
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| CAS No. | 1595275-71-0 | Cat. No. | BCP46386 |
| Name | SG3199 | ||
| Synonyms | SG-3199; SG 3199; | ||
| SMILES | CC1=CN2C(C1)C=NC3=CC(=C(C=C3C2=O)OC)OCCCCCOC4=C(C=C5C(=C4)N=CC6CC(=CN6C5=O)C)OC | ||
| Chemical Name | |||
| Formula | C33H36N4O6 | M. Wt | 584.66 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SG3199 is a PBD dimer warhead component of antibody-drug conjugate (ADC) payload tesirine, demonstrates potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with mean GI50 of 151.5 pM; high-efficiently causes DNA interstrand cross-links in cancer cells; ADCT-402 (loncastuximab tesirine) is a novel CD19-targeted ADC delivering SG3199, ADCT-402 is highly potent, dose-dependent antitumor activity in several subcutaneous and disseminated human tumor models with marked superiority to comparator ADCs delivering tubulin inhibitors. | ||
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