Mitapivat New
Data Sheet
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| CAS No. | 1260075-17-9 | Cat. No. | BCP19727 |
| Related Products | 2329710-91-8（Mitapivat sulfate anhydrous） | ||
| Name | Mitapivat | ||
| Synonyms | PKR-IN-1; PKM2 activator 1020; PKM2 activator;AG348;AG-348;AG 348; | ||
| SMILES | O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O | ||
| Chemical Name | |||
| Formula | C24H26N4O3S | M. Wt | 450.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Mitapivat is an orally available, small-molecule, allosteric activator of the red cell isoform of pyruvate kinase (PK-R), with potential to improve hemolytic anemia in patients with pyruvate kinase deficiency (PKD). Upon oral administration, mitapivat binds to and activates PK-R, thereby enhancing glycolytic pathway activity, improving adenosine triphosphate (ATP) levels and reducing 2,3-diphosphoglycerate (2,3-DPG) levels. Mutations in PK-R cause deficiency in PK-R which prevents adequate red blood cell (RBC) glycolysis, leading to a buildup of the upstream glycolytic intermediate 2,3-DPG and deficiency in the PK-R product ATP. | ||
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