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DASA-58 Chemical Structure

DASA-58

Data Sheet For research use only. Not for human use.
Cat. No. :BCP16322CAS No. :1203494-49-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1203494-49-8 Cat. No. BCP16322
Name DASA-58
Synonyms DASA58;DASA 58; ML-203; ML 203; ML203; NCGC00185916; NCGC-00185916; NCGC 00185916;
SMILES
Chemical Name
Formula C19H23N3O6S2 M. Wt 453.53
Purity 98% Storage Store at 4-8°C
Description DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells).DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins.Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β.It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice.
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