Cranad 2 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP25913CAS No. ：1193447-34-5Purity：98%

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CAS No.	1193447-34-5	Cat. No.	BCP25913
Name	Cranad 2
Synonyms	Cranad-2; Cranad2;
SMILES	[B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F
Chemical Name
Formula	C25H27BF2N2	M. Wt	404.31
Purity	98%	Storage	Store at 4-8°C
Description	Cranad 2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.