Hot Sales
| Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP14029 | BLZ945 New Hot | 953769-46-5 |
BLZ945 is a brain-penetrant CSF-1R inhibitor. The biochemical IC50 for CSF-1R is 1 nM, which is >3200-fold higher than its affinity for other kinases.
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BCP02893 | Belnacasan New Hot | 273404-37-8 |
Belnacasan (VX-765) is an orally absorbed prodrug of VRT-043198, which exhibits potent inhibition against ICE/caspase-1 and caspase-4 with Ki of 0.8 nM and less than 0.6 nM, respectively.
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BCP17155 | Linerixibat New Hot Discount | 1345982-69-5 |
GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) .
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BCP49005 | 2-Aminomethyl-18-crown-6 Hot | 83585-61-9 |
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BCP24760 | K-selectride Hot | 54575-49-4 |
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BCP01873 | A-769662 New Hot | 844499-71-4 |
A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers.
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BCP03687 | Purmorphamine New Hot | 483367-10-8 |
Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
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BCP27641 | Cabazitaxel Hot | 183133-96-2 |
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
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BCP06938 | Nicotinamide Riboside Hot | 1341-23-7 |
Nicotinamide riboside is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
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BCP02328 | Momelotinib Hot | 1056634-68-4 |
Momelotinib, also known as CYT387, is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions.
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BCP07998 | Bevacizumab New Hot | 216974-75-3 |
Bevacizumab is a recombinant humanized monoclonal antibody that blocks angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A).
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BCP07838 | Delamanid New Hot | 681492-22-8 |
Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex.
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BCP35590 | GS441524 New Hot Bulk | 1191237-69-0 |
GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir]. This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-441524 is less potent. GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis Virus, a coronavirus that only infects cats.
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BCP08298 | D-Luciferin k Salt Hot | 115144-35-9 |
D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects.
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BCP00227 | 3,4-Diaminofurazan Hot Discount Bulk | 17220-38-1 |
3,4-Diaminofurazan is a building block used to prepare magnesium and zinc alkynylated salicylaldehyde-diamine Schiff base complexes.
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BCP20294 | Eprenetapopt New Hot Discount | 5291-32-7 |
APR-246 restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1Met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
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BCP25281 | Temsirolimus New Hot | 162635-04-3 |
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay.
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BCP05996 | Vortioxetine New Hot | 508233-74-7 |
Vortioxetine (Lu AA21004) is an investigational novel antidepressant with multimodal activity that functions as a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter in vitro.
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BCP02422 | Favipiravir New Hot | 259793-96-9 |
Favipiravir, also known as T705, is a RNA-directed RNA polymerase NS5B inhibitor
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BCP19778 | Repotrectinib New Hot | 1802220-02-5 |
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
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