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HCV Protease

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HCV Protease

Chemical Structure Cat. No. Product Name CAS No.
ITMN 4077 Chemical Structure
 BCP24014 ITMN 4077 790305-05-4
ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC50: 2131 nM).
Voxilaprevir Chemical Structure
 BCP24118 Voxilaprevir 1535212-07-7
Voxilaprevir (GS-9857) is a potent HCV NS3/4A protease inhibitor that is used in combination with sofosbuvir and velpatasvir for treatment of HCV infection.
Ciluprevir Chemical Structure
 BCP24756 Ciluprevir 300832-84-2
Ciluprevir is an orally bioavailable, peptidomimetic, macrocyclic compound with activity against hepatitis C virus (HCV). Ciluprevir binds non-covalently to the active center of the HCV NS3-4A serine protease and prevents processing of viral proteins required for replication.
U 18666A Chemical Structure
 BCP41254 U 18666A 3039-71-2
U 18666A is a cell-permeable and amphiphilic amino-steroid that inhibits cholesterol synthesis and cellular transport via the suppression of 2,3-oxidosqualene-lanosterol cyclase activity. U 18666A also acts as a weak inhibitor of hedgehog (Hh) signaling. It has been shown to reduce serum sterol levels in rats in vivo.
IDX 320 Chemical Structure
 BCP34858 IDX 320 1251165-81-7
IDX320 is a potent non-covalent macrocyclic inhibitor of the HCV NS3/4A protease.
Grazoprevir potassium Chemical Structure
 BCP34806 Grazoprevir potassium 1206524-86-8
Grazoprevir potassium is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
Boceprevir D9 Chemical Structure
 BCP21353 Boceprevir D9 1256751-11-7
Beclabuvir Chemical Structure
 BCP11013 Beclabuvir 958002-33-0
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM.
MK-4882 Chemical Structure
 BCP13058 MK-4882 1246472-08-1
MK-4882 is a potent HCV NS5A inhibitor.
Elbasvir Chemical Structure
 BCP29961 Elbasvir 1370468-36-2
Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.
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