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Raw Materials
CFTR
Chemical Structure | Cat. No. | Product Name | CAS No. |
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BCP49476 | MRT-5005 New | MRT-5005 | |
MRT5005 is a drug designed to restore CFTR function by delivering correct copies of CFTR-encoded mRNA to the lungs.
|
BCP48256 | RTC13 New | 313530-30-2 | |
RTC13 is a premature termination codon (PTC) readthrough inducer that acts by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
|
BCP21194 | Icenticaftor New | 1334546-77-8 | |
Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively.
|
BCP43623 | Crinecerfont hydrochloride New | 321839-75-2 | |
Crinecerfont is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein.
|
BCP35907 | Elexacaftor R enantiomer New | 2229860-99-3 | |
Elexacaftor (VX-445,) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
|
BCP19794 | Deutivacaftor New | 1413431-07-8 | |
Deutivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator potentially for the treatment of cystic fibrosis.
|
BCP29711 | Elexacaftor New | 2216712-66-0 | |
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). CFTR corrector 1 (compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
|
BCP30546 | FDL169 New | 1628416-28-3 | |
FDL169 is an experimental therapy for cystic fibrosis (CF) that is being developed by Flatley Discovery Lab.
|
BCP29456 | VX-659 | 2204245-48-5 | |
VX-659 is a CFTR protein inhibitor.
|
BCP25130 | ABBV-2222 | 1918143-53-9 | |
ABBV-2222, also known as GLPG2222, is a CFTR corrector being studied for the treatment of cystic fibrosis (CF).
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