STX-0119 New
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| CAS No. | 851095-32-4 | Cat. No. | BCP25956 |
| Name | STX-0119 | ||
| Synonyms | STX0119; STX 0119; | ||
| SMILES | C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)NC4=NN=C(O4)C5=CC=CO5 | ||
| Chemical Name | |||
| Formula | C22H14N4O3 | M. Wt | 382.37 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes (c-myc, survivin, cyclin D1, HIF-1α and VEGF) and stem cell-associated genes (CD44, Nanog, nestin and CD133) as well as the induction of apoptosis in one stem-like cell line. | ||
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