STX-0119
| CAS No. | 851095-32-4 | Cat. No. | BCP25956 |
| Name | STX-0119 | ||
| Synonyms | STX0119; STX 0119; | ||
| Formula | C22H14N4O3 | M. Wt | 382.37 |
| Description | STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes (c-myc, survivin, cyclin D1, HIF-1α and VEGF) and stem cell-associated genes (CD44, Nanog, nestin and CD133) as well as the induction of apoptosis in one stem-like cell line. | ||
| Pathways | Jak/Stat Pathway Wnt/Stem Cell | ||
| Targets | Stat | ||
Structure
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