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AUY954 Chemical Structure

AUY954

Data Sheet For research use only. Not for human use.
Cat. No. :BCP33492CAS No. :820240-77-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 820240-77-5 Cat. No. BCP33492
Name AUY954
Synonyms NVP-AUY954;AUY-954;AUY 954;
SMILES C1=CC=C(C=C1)C2=C(C=C(C=C2)C3=CC4=C(S3)C=CC(=C4)CNCCC(=O)O)C(F)(F)F
Chemical Name
Formula C25H20F3NO2S M. Wt 455.49
Purity 98% Storage Store at 4-8°C
Description AUY-954 is a potent and selective S1P(1) modulator. AUY-954 prevents experimental autoimmune neuritis. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment. Therefore, S1P(1) modulation might be a potential treatment option for inflammatory neuropathies.
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